The science
Korean exosome science, an academic foundation.
The BAE Lab boosters are developed by BAE Lab, a stem-cell research laboratory founded in 2018 at Soongsil University, Seoul — built on a patented EV membrane filter and bio-inspired, nano-defined cell culture. Part of the wider shift toward skin longevity: results built to hold up over the long term, not just a short-term shine.
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BAE Lab / Soongsil University research imagery
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The terms
Exosomes, polynucleotides and glass skin, in plain terms.
What is an exosome?
An exosome is a nanoscale vesicle that carries active molecules — RNA, proteins, peptides — between cells. In skincare, exosomes act as a delivery vehicle that ferries actives across the skin barrier. Exotokine uses 100% plant-derived exosomes from Centella Asiatica — no animal or human origin.
What is PDRN?
PDRN (polydeoxyribonucleotide) is a polynucleotide — a chain of DNA fragments — that activates the A2A receptor to help drive tissue regeneration and calm inflammation. Pidiroenne uses plant-sourced Stable-PN PDRN from Rose & Soy, engineered for more consistent results than common salmon-derived PDRN.
What is a polynucleotide?
A polynucleotide is a chain of nucleotides — the building blocks of DNA. PDRN (polydeoxyribonucleotide) is the polynucleotide used in skin boosters; “PN” and “PDRN” are often used interchangeably in the category. It's the active behind the “salmon DNA facial” trend, and the ingredient inside Pidiroenne.
Is plant PDRN the same as salmon PDRN?
Both are polydeoxyribonucleotide (PDRN), but the source differs. Most PDRN on the market is salmon-derived — the origin behind the “salmon sperm facial”. Pidiroenne uses BAE Lab's patented Stable-PN technology, sourced from Rose & Soy instead of fish — engineered for more consistent, allergy-free regeneration through the same A2A activation pathway.
What is glass skin?
Glass skin is the aesthetic of smooth, poreless-looking, luminous skin — as if lit from within. It's a look, not a medical outcome: the combination of deep hydration, an even tone and a healthy barrier. Exotokine's plant-exosome delivery and Tocoforte's multivitamin complex are formulated for that glass-skin finish, in-clinic.
Scientific background
The biology the boosters act on.
Every formula in the range works through the same set of mechanisms. Understand these six and the composition of each product reads as a sequence of deliberate decisions, not a list of ingredients.
Extracellular vesicles
Nanoscale, membrane-bound packages cells use to send instructions to one another. They carry an RNA, protein and lipid cargo and deliver it intact — the natural courier system the boosters borrow to cross the skin barrier.
Cell-to-cell communication
Skin regeneration is coordinated by signals passed between cells. Exosomes and growth factors carry those signals directly to keratinocytes and fibroblasts, telling them to repair, proliferate and rebuild.
Fibroblast activation
Fibroblasts are the cells that produce collagen and elastin. Growth factors, PDRN and Centella actives stimulate fibroblast proliferation and type I collagen synthesis — the engine of firmer, more resilient skin.
ECM remodeling
The extracellular matrix is the collagen-and-elastin scaffold skin is built on. Regeneration means remodeling that matrix — new, better-organised structure replacing degraded tissue.
Skin-barrier restoration
A healthy barrier holds water in and irritants out. Increasing ceramide synthesis and reducing transepidermal water loss (TEWL) restores barrier integrity — the difference between temporary hydration and lasting resilience.
Oxidative-stress reduction
Reactive oxygen species degrade proteins, lipids and DNA, accelerating visible ageing. Antioxidant networks — glutathione, Vitamins C and E — neutralise them and protect the cellular machinery of repair.
Ingredient library
Every active in the range, with its biology, mechanism, molecular weight and synergy — searchable, one page each.
BAE Lab
Soongsil University, Seoul, Korea
Led by Prof. Won-Gyu Bae — PhD, Seoul National University; Post-Doctorate, Stanford University. A research house dedicated to beauty and medical products based on biomimetics.
- Founded 2018 — stem-cell research laboratory
- Patented EV Membrane Filter (multi-stage micro/nano)
- Bio-inspired, nano-defined cell culture
- Stable-PN technology for PDRN formulation
- Certifications: ISO, CPNP (EU), GCC, UK-compliant
- Distributed in the Balkans by Allure Beauty
Three technologies
One botanical system, three mechanisms.
Plant exosome technology
BAE Lab’s patented multi-stage micro/nano membrane filtration extracts extracellular vesicles from Centella Asiatica at 0.1% purity — the delivery vehicle behind Exotokine and Exotokine Black.
Stable-PN PDRN
A plant-sourced polydeoxyribonucleotide from Amber Rose & Soy — engineered for more consistent results than common salmon PDRN, with none of the fish-protein allergy or animal-origin concerns. The core active behind Pidiroenne, delivering up to 80% improvement in the appearance of scars.
Multivitamin delivery
Tocoforte formulates Vitamins C, E, B3 and B5 for transdermal, in-clinic delivery — the difference between a vitamin product and a vitamin result.
The technology
From plant callus to inside the cell.
A plant exosome is only as good as the process that isolates it and the delivery that gets it past the barrier. Six stages, from culture to cellular uptake.
- 01
Isolation
Extracellular vesicles are drawn from Centella Asiatica callus culture — plant-sourced, no animal or human origin.
- 02
Purification
A patented multi-stage micro/nano membrane filter separates and concentrates the vesicles to a defined 0.1% purity.
- 03
Vesicle sizing
Nanoscale vesicles are characterised by size distribution — small enough to cross the barrier and reach living cells.
- 04
Stability
Controlled culture and formulation keep the cargo intact and the batch consistent — not donor-dependent like animal-derived material.
- 05
Delivery
In-clinic devices (microneedling, RF, laser channels) drive the vesicles transdermally, past the barrier a home serum sits on.
- 06
Cellular uptake
Vesicles fuse with target cells and release their cargo, activating the repair and signaling cascades directly inside the cell.
Why botanical
Plant-based exosomes vs. animal-derived products.
| Parameter | Animal exosomes | Exotokine (plant-based) |
|---|---|---|
| Source | Animal stem cells | Centella Asiatica (100% plant) |
| Ethical concerns | Animal welfare | No ethical production concerns |
| Contamination | Viral / prion transmission risk | No human / animal pathogen risk |
| Stability | Variable (donor-dependent) | Stable (controlled culture) |
| Regulatory | Stricter for human origin | EU / GCC cosmetic compliant |
In-vitro evidence
Measured, not marketed.
- · PP-Exosome heals wounds faster than control groups.
- · Increased macrophage recruitment (Iba-1).
- · Enhanced angiogenesis (α-SMA on day 14).
- · PDRN increases fibroblasts at 20–100 µg/ml; stimulates VEGF.
- · Documented 22-day wound recovery with Exotokine + Pidiroenne.
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In-vitro / clinical evidence figure
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How the material is characterised
A plant exosome is only credible if it is measured. These are the dimensions BAE Lab characterises its material on — the QA layer behind an ISO-certified, EU/GCC-compliant cosmetic.
EV concentration
How many vesicles are actually present per dose.
Particle-size distribution
The nanoscale size range that lets vesicles cross the barrier.
Particle characterisation
Confirming the isolate is genuine extracellular vesicles.
Stability testing
That the cargo and batch hold up over shelf life.
Sterility testing
A clean, contamination-free professional-use product.
Purity
The defined 0.1% plant-exosome concentration, no animal or human origin.
Characterisation dimensions, not batch-specific results. Full specification and test data available to stocking clinics and distributors on request.